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Anti-RPS6KA1 Antibody E4
Also for RPS6KA1 (NM_002953)
|A synthetic peptide corresponding to residues in N-terminus of human p90-RSK1 was used as immunogen.|
|Mouse, Rat, Human, Pig
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC: 1:200; FC: 1:50; IP: 1:10
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1|
|HU-1; MAPKAPK1A; RSK; RSK1|
Entrez Gene 6195 Human
Entrez Gene 20111 Mouse
Entrez Gene 81771 Rat
|RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).|
EGFR1 Signaling Pathway
MAPK signaling pathway
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Western blot - Anti-RSK1 p90 antibody [E4]; Anti-RSK1 p90 antibody [E4] at 1/1000 dilution + MCF7 cell lysate at 10 ug.Predicted band size : 83 kDa.Observed band size : 90 kDa .
Immunohistochemistry (Paraffin-embedded sections) - RSK1 p90 antibody [E4]; Ab32114, at a 1/100 dilution, staining RSK1 p90 in paraffin embedded human colon tissue by immunohistochemistry.