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Home Antibody All anti-RIPK2 antibodies

Anti-RIPK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305984
  • Rabbit Polyclonal RICK Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418408) , 20ug
100ug 325 In Stock
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WB(1)
IF(1)
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Also for RIPK2 (NM_003821)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2)
Alternative NameCARD3; CARDIAK; CCK; GIG30; RICK; RIP2
Database LinkNP_003812
FunctionApoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
IF Image
Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 ug/mL.

 

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