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Home Antibody All anti-RIPK1 antibodies

Anti-RIPK1 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319759
  • Rabbit Polyclonal RIP1 Antibody
100ug 325 3-7 Days
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IHC(1)
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Also for RIPK1 (NM_003804)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRIP1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsELISA, IHC: 5 - 10 ug/ml
Predicted MW Explanation 74 kDa
BufferRIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification RIP1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
Alternative NameRIP; RIP1
Database LinkNP_003795
Entrez Gene 8737 Human
FunctionRIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
Related PathwayProtein KinaseDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry of RIP1 in human placenta tissue with RIP1 antibody at 10 ug/mL.

 

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