Home Antibody All anti-RIPK1 antibodies
Anti-RIPK1 Antibody Polyclonal
Also for RIPK1 (NM_003804)
|RIP1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.|
||ELISA, IHC: 5 - 10 ug/ml
|RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|RIP1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)|
Entrez Gene 8737 Human
|RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.|
|Protein KinaseDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway|
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Immunohistochemistry of RIP1 in human placenta tissue with RIP1 antibody at 10 ug/mL.