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Home Antibody All anti-RIPK1 antibodies

Anti-RIPK1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306838 Rabbit Polyclonal RIPK1 Antibody 100ug $325 2 Weeks
LC401251 RIPK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for RIPK1 (NM_003804)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRIPK1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human RIPK1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1)
Alternative NameRIP; RIP1
Database LinkNP_003795
Entrez Gene 8737 Human
Entrez Gene 19766 Mouse
Entrez Gene 306886 Rat
FunctionRIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIPK1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
Related PathwayProtein KinaseDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 µg/ml.

IHC Image
Immunohistochemistry of RIPK1 in mouse kidney tissue with RIPK1 antibody at 2.5 ug/ml.

IF Image
Immunofluorescence of RIPK1 in Mouse Kidney cells with RIPK1 antibody at 20 ug/mL.


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