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Home Antibody All anti-RIC8A antibodies

Anti-RIC8A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302971
  • Goat Polyclonal Antibody against RIC8A
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402886) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for RIC8A (NM_021932)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen Peptide with sequence CLSSDPDSDPD, from the C Terminus of the protein sequence according to NP_068751.4.
Clone Name IsotypeGoat IgG
Species ReactivityHuman Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:32,000. WB: 1-3µg/ml.
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens RIC8 guanine nucleotide exchange factor A (RIC8A), transcript variant 1
Alternative NameRIC8
Database LinkNP_068751
FunctionGuanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation
Related Pathway

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WB Image
TA302971 staining (1µg/ml) of human brain lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

 

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