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Anti-RHOA Antibody Y486
Also for RHOA (NM_001664)
|A synthetic peptide corresponding to residues in the N-term of human Rho was used as immunogen. The antibody is predicted to detect RhoA, RhoB and RhoC based on sequence analysis.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens ras homolog family member A (RHOA)|
|ARH12; ARHA; RHO12; RHOH12|
Entrez Gene 387 Human
Entrez Gene 11848 Mouse
Entrez Gene 117273 Rat
|Rho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families; the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on of off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extend cell transformation (5). |
|Druggable Genome Chemokine signaling pathwayVascular smooth muscle contractionWnt signaling pathwayTGF-beta signaling pathwayAxon guidanceFocal adhesionMore Pathways >> |
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Western blot - Rho antibody [Y486]; Anti-Rho antibody [Y486] at 1/2000 dilution + PC12 cell lysate.Predicted band size : 21 kDa.Observed band size : 22 kDa .
Immunohistochemistry (Paraffin-embedded sections) - Rho antibody [Y486]; Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using TA300526 at 1/100 dilution.