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Home Antibody All anti-RHOA antibodies

Anti-RHOA Antibody Y486

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300526
  • Rabbit Monoclonal Antibody against RHOA (Clone Y486)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400630) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for RHOA (NM_001664)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-term of human Rho was used as immunogen. The antibody is predicted to detect RhoA, RhoB and RhoC based on sequence analysis.
Clone NameY486 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens ras homolog family member A (RHOA)
Alternative NameARH12; ARHA; RHO12; RHOH12
Database LinkNP_001655
Entrez Gene 387 Human
Entrez Gene 11848 Mouse
Entrez Gene 117273 Rat
FunctionRho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families; the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on of off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extend cell transformation (5).
Related PathwayDruggable Genome Chemokine signaling pathwayVascular smooth muscle contractionWnt signaling pathwayTGF-beta signaling pathwayAxon guidanceFocal adhesionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Rho antibody [Y486]; Anti-Rho antibody [Y486] at 1/2000 dilution + PC12 cell lysate.Predicted band size : 21 kDa.Observed band size : 22 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Rho antibody [Y486]; Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using TA300526 at 1/100 dilution.

 

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