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Home Antibody All anti-RHBDD1 antibodies

Anti-RHBDD1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306890 Rabbit Polyclonal RHBDD1 Antibody 100ug $325 3-7 Days
LC432870 RHBDD1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRHBDD1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human RHBDD1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens rhomboid domain containing 1 (RHBDD1), transcript variant 2
Alternative NameRRP4
Database LinkNP_001161080
Entrez Gene 84236 Human
Entrez Gene 76867 Mouse
FunctionThe Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RHBDD1 in K562 cell lysate with RHBDD1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.


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