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Anti-RET TRUEMAB Antibody Clone 4H3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA805744
  • RET mouse monoclonal antibody,clone 4H3
100ul $325 In Stock
CF805744
  • Carrier-free (BSA/glycerol-free) RET mouse monoclonal antibody,clone 4H3
100ug $450 3 Days
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WB(1)
IHC(2)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 713-1017 of human RET(NP_066124) produced in E.coli.
Clone NameClone 4H3 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:500, IHC 1:150,
Predicted MW Explanation 124.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens ret proto-oncogene (RET), transcript variant 2
Alternative NameCDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51
Database LinkNP_066124
Entrez Gene 5979 Human
FunctionThis gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
Related PathwayProtein KinaseTransmembraneDruggable Genome EndocytosisPathways in cancerThyroid cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RET (RC214268, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RET.
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Immunohistochemical staining of paraffin-embedded Carcinoma of RET positive Human lung tissue using anti-RET mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805744)
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Immunohistochemical staining of paraffin-embedded Carcinoma of RET positive Human lung tissue using anti-RET mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805744)
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