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Home All anti-RELA antibodies
Anti-RELA Phospho Antibody EPR2379
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for RELA (NM_021975)
OriGene Data
| A phospho specific peptide corresponding to residues surrounding serine 529 of human NF-kappa-B was used as an immunogen. This antibody only detects NF-kappa-B phosphorylated at serine 529. |
| EPR2379 |
Rabbit IgG |
| Human |
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| WB |
FC: 1:100 - 500, IP: 1:10 - 100, WB: 1:1,000 - 10,000, |
| 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA), transcript variant 1 |
| NFKB3; p65 |
| NP_068810 |
| Nuclear factor B (NF-B) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes (1). They play a role as transcription factors in the adaptive immune response, inflammation, and apoptosis (2). The p65 subunit, similar to two others in the B family, RelB and c-Rel, contains two transactivation domains in the C-terminal region of the protein (3). Association with inhibitory proteins of the IκB family retains NF-κB in the cytoplasm. Degradation of IB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-κB to DNA (4). p65 phosphorylation events occur in the cytoplasm or nucleus and are stimuli- and cell-type specific, on serines 276, 529, and 536 by various kinases: i.e. PKA, casein kinase II, IKK beta, and RSK1. Phosphorylation on these sites has been linked to the regulation of NF-κB activation (5). |
Apoptosis Delta-Notch Signaling Pathway MAPK signaling pathway Toll-like receptor signaling pathway |
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* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis on Daudi cell lysates using anti-Phospho-NF-kappa-B (pS529) RabMAb .
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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