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Anti-RELA Phospho Antibody EPR2379
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Also for RELA (NM_021975)
|A phospho specific peptide corresponding to residues surrounding serine 529 of human NF-kappa-B was used as an immunogen. This antibody only detects NF-kappa-B phosphorylated at serine 529.|
||FC: 1:100 - 500, IP: 1:10 - 100, WB: 1:1,000 - 10,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA), transcript variant 1|
|Nuclear factor B (NF-B) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes (1). They play a role as transcription factors in the adaptive immune response, inflammation, and apoptosis (2). The p65 subunit, similar to two others in the B family, RelB and c-Rel, contains two transactivation domains in the C-terminal region of the protein (3). Association with inhibitory proteins of the IκB family retains NF-κB in the cytoplasm. Degradation of IB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-κB to DNA (4). p65 phosphorylation events occur in the cytoplasm or nucleus and are stimuli- and cell-type specific, on serines 276, 529, and 536 by various kinases: i.e. PKA, casein kinase II, IKK beta, and RSK1. Phosphorylation on these sites has been linked to the regulation of NF-κB activation (5).|
Delta-Notch Signaling Pathway
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot analysis on Daudi cell lysates using anti-Phospho-NF-kappa-B (pS529) RabMAb .