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Home Antibody All anti-RB1 antibodies

Anti-RB1 PHOSPHO Antibody EPR224

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307722
  • Rabbit monoclonal antibody against RB Phospho (pS811)(clone EPR224) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 811 of human Rb was used as an immunogen. This antibody only detects Rb phosphorylated at Serine 811.
Clone NameEPR224 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens retinoblastoma 1 (RB1)
Alternative NameOSRC; p105-Rb; pp110; pRb; RB
Database LinkNP_000312
FunctionRetinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdks inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Related Pathway
Adipogenesis
Cell cycle
Senescence and Autophagy
TGF Beta Signaling Pathway

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WB Image
Western blot - Anti-Rb (phospho S811) antibody [EPR224]; All lanes : Anti-Rb (phospho S811) antibody [EPR224] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Jurkat cell lysate treated with FBS.Lysates/proteins at 10 µg per lane.Predicted band size : 106 kDa.

 

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