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Home Antibody All anti-RB1 antibodies

Anti-RB1 PHOSPHO Antibody E182

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA303682
  • Rabbit monoclonal antibody against Phospho-Rb (S780)(E182) (phospho-specific)
100ul $325 3-7 Days

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WB(1)
IF(1)

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Ser780 of human Rb was used as immunogen. The antibody only detects Rb phosphorylated on Serine 780.
Clone NameE182 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500 - 1000; ICC: 1:250-1:500; IP: 1:40
Predicted MW Explanation 106 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens retinoblastoma 1 (RB1)
Alternative NameOSRC; p105-Rb; pp110; pRb; RB
Database LinkNP_000312
Entrez Gene 5925 Human
FunctionThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq].
Related PathwayTranscription FactorsDruggable Genome Cell cyclePathways in cancerPancreatic cancerGliomaProstate cancerMelanomaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Rb (phospho S780) antibody [E182]; All lanes : Anti-Rb [E182] antibody at 1/1000 dilution.Lane 1 : Untreated Jurkat cell lysate.Lane 2 : Jurkat cell lysate treated with FBS.Lane 3 : Jurkat cell lysate treated with Alkaline Phosphatase.Predicted band size : 106 kDa.Observed band size : 110 kDa .
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Immunocytochemistry/ Immunofluorescence - Rb (phospho S780) antibody [E182]; Immunofluorescent staining of (A) non-treated and (B) Lambda Phosphatase-treated A431 cells using anti-Phospho-Rb (S780) TA303682 Rabbit Monoclonal Antibody
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