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Home Antibody All anti-RASGRP4 antibodies

Anti-RASGRP4 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308102 Rabbit Polyclonal antibody to RASGRP4 (RAS guanyl releasing protein 4) 100ul $325 3-7 Days
LC406913 RASGRP4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 108 and 200 of RASGRP4 (Uniprot ID#Q8TDF6)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 75kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens RAS guanyl releasing protein 4 (RASGRP4), transcript variant a
Alternative Nameguanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4
Database LinkNP_733749
Entrez Gene 115727 Human
FunctionThe protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayDruggable Genome MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate). A: Jurkat. 7.5% SDS PAGE. TA308102 diluted at 1:1000.
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Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using RASGRP4 (TA308102) antibody at 1:100 dilution.
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Immunofluorescence analysis of methanol-fixed HeLa, using RASGRP4(TA308102) antibody at 1:500 dilution.
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