Anti-RASA1 Antibody, Clone 2H1

Also for RASA1 (NM_002890)

OriGene Data

Immunogen	Full length human recombinant protein of human RASA1(NP_002881) produced in HEK293T cell.
Clone Name	Clone 2H1	Isotype	IgG1
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IF	Suggested Dilutions	WB 1:2000, IF 1:100,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1
Alternative Name	CM-AVM; CMAVM; GAP; p120GAP; p120RASGAP; PKWS; RASA; RASGAP
Database Link	NP_002881
Function	The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
Related Pathway	EGFR1 Signaling Pathway MAPK signaling pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASA1 (RC205473, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASA1.

IF Image

Anti-RASA1 mouse monoclonal antibody (TA505900) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASA1(RC205473).

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OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-RASA1 TrueMAB Antibody Clone 2H1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data