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Anti-RARA Antibody EP1823Y
Also for RARA (NM_000964)
|A synthetic peptide corresponding to residues near N-terminal of human RAR alpha protein was used as an immunogen.|
||Tissue culture supernatant
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1:1000; FC: 1:50
|Does not react with Rat. Is unsuitable for ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens retinoic acid receptor, alpha (RARA), transcript variant 1|
Entrez Gene 5914 Human
Entrez Gene 19401 Mouse
|The retinoic acid receptors (RARs) are family of nuclear receptors that mediates effects of retinoic acid (RA, acidified form of vitamin A), a non-steroid hormone involved in cell proliferation, differentiation, and apoptosis (1). Three isoforms of RAR exists (RAR alpha, beta, and gamma) and forms a heterodimer with RXRs (retinoid X receptor, a distant related receptor). When bound to RA, RARs acts as transcription factors and binds to thyroid hormone response element or RA response element (RARE), activating gene expression (2). RAR alpha has been implicated as important biomedical marker in the pathogenesis of acute promyelocytic leukemia (APL) (3). |
|Nuclear Hormone ReceptorTranscription FactorsDruggable Genome Pathways in cancerAcute myeloid leukemia|
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Western blot - Retinoic Acid Receptor alpha antibody [EP1823Y]; Anti-Retinoic Acid Receptor alpha antibody [EP1823Y] at 1/1000 dilution + MCF-7 cell lysate at 10 ug.Predicted band size : 51 kDa.Observed band size : 55 kDa .
Flow Cytometry - Retinoic Acid Receptor alpha antibody [EP1823Y]; Flow cytometric analysis of permeabilized MCF-7 cells using TA300976 at 1/50 dilution (red) or a rabbit IgG (negative) (green).