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Home Antibody All anti-RAPGEF3 antibodies

Anti-RAPGEF3 Antibody EPR1672


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307796 Rabbit monoclonal antibody against Epac1(clone EPR1672) 100ul $325 In Stock
LC401841 RAPGEF3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for RAPGEF3 (NM_006105)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus of human Epac1 was used as an immunogen.
Clone NameEPR1672 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
Predicted MW Explanation 104 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 2
Alternative Namebcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Database LinkNP_006096
Entrez Gene 10411 Human
Entrez Gene 223864 Mouse
Entrez Gene 59326 Rat
FunctionEpac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of its GEF domain with Rap, resulting in Rap activation and subsequent downstream effects, including integrin-mediated cell adhesion and cell-cell junction formation (1). In addition, activation of Epac1 has been shown to promote cell adhesion and polarization and enhance chemokine-induced migration (2).
Related Pathway Leukocyte transendothelial migrationLong-term potentiation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Epac1 antibody [EPR1672]; All lanes : Anti-Epac1 antibody [EPR1672] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Human heart lysate.Lane 4 : HUVEC cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 104 kDa.

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Epac1 antibody [EPR1672]; Immunohistochemical analysis of Epac1 in paraffin-embedded Human kidney tissue using TA307796 at 1/50 dilution.


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