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Anti-RAPGEF3 Antibody EPR1672
Also for RAPGEF3 (NM_006105)
|A synthetic peptide corresponding to residues in C-terminus of human Epac1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 2|
|bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275|
|Epac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of its GEF domain with Rap, resulting in Rap activation and subsequent downstream effects, including integrin-mediated cell adhesion and cell-cell junction formation (1). In addition, activation of Epac1 has been shown to promote cell adhesion and polarization and enhance chemokine-induced migration (2).|
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Western blot - Epac1 antibody [EPR1672]; All lanes : Anti-Epac1 antibody [EPR1672] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Human heart lysate.Lane 4 : HUVEC cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 104 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Epac1 antibody [EPR1672]; Immunohistochemical analysis of Epac1 in paraffin-embedded Human kidney tissue using ab109415 at 1/50 dilution.