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Anti-RANBP3 Antibody EPR5088(2)


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  • Rabbit Monoclonal antibody against RanBP3
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RanBP3 was used as an immunogen.
Clone NameEPR5088(2) IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:100 - 1:500
Predicted MW Explanation 60 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a
Alternative NameDKFZp586I1520
Database LinkNP_003615
Entrez Gene 8498 Human
Entrez Gene 71810 Mouse
FunctionRanBP3 is a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. It plays a role in nuclear export as part of a heteromeric complex (1). RanBP3 binds to the Crm1 transport receptor and inhibits the binding of unloaded Crm1 to the NPC. In addition, it increases the affinity of Crm1 for both Ran-GTP and nuclear export sequences. In this manner, RanBP3 coordinates efficient cargo loading and RanGTP binding (2). Moreover, RanBP3 has been shown to bind to RCC1 in a Ran-dependent manner and to increase the nucleotide exchange activity of RCC1, resulting in high concentrations of RanGTP in the vicinity of RCC1. Consequently, RanBP3 acts as a scaffold protein by which components of the export complex are concentrated around the RCC1 site, thus promoting complex assembly (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-RanBP3 antibody [EPR5088(2)]; Anti-RanBP3 antibody [EPR5088(2)] at 1/1000 dilution + 293T lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RanBP3 antibody [EPR5088(2)]; Immunohistochemical analysis of paraffin-embedded Human testis tissue labelling RanBP3 with TA310810 at 1/100 dilution.


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