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Anti-RAG2 Antibody EPRAGR239


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against RAG-2
100ul 325 3-7 Days
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OriGene Data

ImmunogenA recombinant protein fragment corresponding to residues in mouse RAG-2 was used as an immunogen.
Clone NameEPRAGR239 IsotypeTissue culture supernatant
Species ReactivityMouse (Does not react with: Rat, Human) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameMus musculus recombination activating gene 2 (Rag2)
Alternative NameRag-2
Database LinkNP_033046
Entrez Gene 19374 Mouse
FunctionRAG-2 is involved in the initiation of V(D)J recombination during B and T cell development. It forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in RAG-2 cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-RAG2 antibody [EPRAGR239 ]; Anti-RAG2 antibody [EPRAGR239 ] at 1/1000 dilution + Mouse thymus lysate at 10 ug.Secondary.HRP labelled Goat anti Rabbit at 1/2000 dilution.Predicted band size : 59 kDa.
WB Image
Western blot - Anti-RAG2 antibody [EPRAGR239 ]; All lanes : Anti-RAG2 antibody [EPRAGR239 ] at 1/1000 dilution.Lane 1 : Whole cell lysate of 293T transiently transfected with MBP-RAG2 core.Lane 2 : Whole cell lysate of 293T untransfected .Lane 3 : Whole cell lysate of thymus from wt Mouse (5 weeks old).Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit at 1/2000 dilution.Predicted band size : 59 kDa.


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