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Home Antibody All anti-RAF1 antibodies

Anti-RAF1 Antibody Y198

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303679
  • Rabbit monoclonal antibody against Raf-1(Y198)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419048) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for RAF1 (NM_002880)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Serine 338-339 of human Raf was used as immunogen.
Clone NameY198 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:50-100; ICC: 1:50; IP: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified

Reference Data

Target NameHomo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1)
Alternative Namec-Raf; CRAF; NS5; Raf-1
Database LinkNP_002871
FunctionThis gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
Melanogenesis
Senescence and Autophagy
Wnt Signaling Pathway

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WB Image
Western blot - Raf1 antibody [Y198]; Anti-Raf1 antibody [Y198] at 1/500 dilution + NIH 3T3 cell lysate.Predicted band size : 73 kDa.Observed band size : 74 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Raf1 antibody [Y198]; TA303679, at a 1/100 dilution, staining human Raf1 in colon carcinoma by Immunohistochemistry, Paraffin embedded tissue

 

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