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Anti-RAD51 Antibody EPR4031
Also for RAD51 (NM_133487)
|A synthetic peptide corresponding to the C-terminal of human Rad51 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC or IHC-P.
|Homo sapiens RAD51 recombinase (RAD51), transcript variant 2|
|BRCC5; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA|
Entrez Gene 5888 Human
Entrez Gene 19361 Mouse
Entrez Gene 499870 Rat
|Rad51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and Rad52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Rad51 is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis (1).|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome Homologous recombinationPathways in cancerPancreatic cancer|
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Western blot - Rad51 antibody [EPR4031]; All lanes : Anti-Rad51 antibody [EPR4031] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : A431 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 36 kDa.