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Home Antibody All anti-RAD50 antibodies

Anti-RAD50 Antibody EPR3466(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310802
  • Rabbit Monoclonal antibody against Rad50
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401747) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Rad50 was used as an immunogen.
Clone NameEPR3466(2) IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens RAD50 homolog (S. cerevisiae) (RAD50)
Alternative NamehRad50; NBSLD; RAD502
Database LinkNP_005723
Entrez Gene 10111 Human
Entrez Gene 19360 Mouse
FunctionRad50 is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. It forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. Rad50, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest Rad50 is essential for cell growth and viability. Mutations in Rad50 are the cause of Nijmegen breakage syndrome-like disorder (1).
Related PathwayDruggable Genome Homologous recombinationNon-homologous end-joining

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Rad50 antibody [EPR3466(2)]; All lanes : Anti-Rad50 antibody [EPR3466(2)] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : MOLT4 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 154 kDa.Observed band size : 150 kDa .

 

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