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Anti-RAD21 Antibody CM110-2C10
Also for RAD21 (NM_006265)
|An N-terminal fusion protein of the C-terminal fragment of Scc1 subunit human cohesin (amino acids 544-631 of hRad21)|
|PBS and 0.1% sodium azide|
|Homo sapiens RAD21 homolog (S. pombe) (RAD21)|
|CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1|
Entrez Gene 5885 Human
Entrez Gene 19357 Mouse
|The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2). |
|Druggable Genome Cell cycle|
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Western blot with monoclonal anti-Rad21 in HEK293 lysates.