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Home Antibody All anti-RAD21 antibodies

Anti-RAD21 Antibody CM110-2C10

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301500
  • Mouse Monoclonal Antibody against Cohesin / hRad21 (CM110-2C10)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401887) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenAn N-terminal fusion protein of the C-terminal fragment of Scc1 subunit human cohesin (amino acids 544-631 of hRad21)
Clone NameCM110-2C10 IsotypeIgG1 kappa
Species Reactivityhuman, mouse Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferPBS and 0.1% sodium azide
Purification IgG purified

Reference Data

Target NameHomo sapiens RAD21 homolog (S. pombe) (RAD21)
Alternative NameCDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1
Database LinkNP_006256
FunctionThe cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2).
Related Pathway
Cell cycle

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WB Image
Western blot with monoclonal anti-Rad21 in HEK293 lysates.

 

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