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Home Antibody All anti-Pmaip1 antibodies

Anti-Pmaip1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306071
  • Rabbit Polyclonal Noxa Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402842) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for Pmaip1 (NM_021127)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNoxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Immunoaffinity chromatography purified IgG

Reference Data

Target NameHomo sapiens phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Alternative NameAPR; NOXA
Database LinkNP_066950
Entrez Gene 5366 Human
Entrez Gene 58801 Mouse
Entrez Gene 492821 Rat
FunctionApoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified , which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 . Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4).
Related Pathway
Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Noxa in human stomach tissue lysate with Noxa antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of Noxa in human stomach tissue with Noxa antibody at 1 ug/ml.

 

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