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Anti-PTS PHOSPHO Antibody EPR1517(2)


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against PTP Synthase Phospho (pS19)(clone EPR1517(2)) (Phospho-Specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 19 of human PTP Synthase was used as an immunogen. This antibody only detects PTP Synthase phosphorylated at Serine 19.
Clone NameEPR1517(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:250 - 1:500; ICC/IF: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens 6-pyruvoyltetrahydropterin synthase (PTS)
Alternative NamePTPS
Database LinkNP_000308
Entrez Gene 5805 Human
FunctionPTP Synthase catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in PTP Synthase result in hyperphenylalaninemia (1). Phosphorylation of Serine 19 is required for maximal enzyme activity (2).
Related PathwayDruggable Genome Folate biosynthesisMetabolic pathways

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Western blot - PTS (phospho S19) antibody [EPR1517(2)]; All lanes : Anti-PTS (phospho S19) antibody [EPR1517(2)] at 1/1000 dilution.Lane 1 : HUVEC cell lysates .Lane 2 : HUVEC cell lysates treated with Alkaline Phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 17 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PTS (phospho S19) antibody [EPR1517(2)]; TA307723, at a 1/250 dilution, staining PTS (phospho S19) in paraffin embedded Human brain tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - PTS (phospho S19) antibody [EPR1517(2)]; TA307723, at a 1/250 dilution, staining PTS (phospho S19) in HeLa cells by Immunofluorescence.


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