Bit1 is a mitochondrial protein that, upon loss of cell attachment, is released from the mitochondria into the cytosol to promote apoptosis. Bit1-induced cell death is independent of caspase activity but requires the presence of AES, a member of the Groucho/TLE family of transcriptional regulators. Suppression of Bit1 expression in tumor cells as well as in normal cells significantly protects cells from detachment-induced apoptosis, demonstrating a key role of Bit1 in anoikis (1). Moreover, Bit1 serves as one of two enzymes that release tRNA from a peptidyl-tRNA complex. Hence, it is also known as peptidyl-tRNA hydrolase 2 (2).
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