Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Bit1 is a mitochondrial protein that, upon loss of cell attachment, is released from the mitochondria into the cytosol to promote apoptosis. Bit1-induced cell death is independent of caspase activity but requires the presence of AES, a member of the Groucho/TLE family of transcriptional regulators. Suppression of Bit1 expression in tumor cells as well as in normal cells significantly protects cells from detachment-induced apoptosis, demonstrating a key role of Bit1 in anoikis (1). Moreover, Bit1 serves as one of two enzymes that release tRNA from a peptidyl-tRNA complex. Hence, it is also known as peptidyl-tRNA hydrolase 2 (2).
Related Pathway
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