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Home Antibody All anti-PTPN11 antibodies

Anti-PTPN11 TRUEMAB Antibody clone 1F7

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA501914
  • PTPN11 (SHP2) mouse monoclonal antibody, clone 1F7
100ul 325 In Stock
CF501914
  • Carrier-free (BSA/glycerol-free) PTPN11 mouse monoclonal antibody, clone 1F7
100ug $450 3-4 Days
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WB(1)
FC(2)
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Also for PTPN11 (NM_002834)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
Clone Nameclone 1F7 IsotypeIgG1
Species ReactivityHuman Concentration0.86 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB 1:1000, FLOW 1:100
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1
Alternative NameBPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Database LinkNP_002825
FunctionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
Jak-STAT signaling pathway

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WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN11 (RC220029, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTPN11.
FC Image
Flow cytometric Analysis of Hela cells, using anti-PTPN11 antibody(TA501914),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
FC Image
Flow cytometric Analysis of Jurkat cells, using anti-PTPN11 antibody(TA501914),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).

 

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