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Anti-PTPN11 TRUEMAB Antibody Clone OTI3F2
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for PTPN11 (NM_002834)
|Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.|
|Human , Dog
||WB 1:500~2000, FLOW 1:100
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1|
|BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2|
Entrez Gene 5781 Human
Entrez Gene 477488 Dog
|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]. |
|PhosphataseDruggable Genome Jak-STAT signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationNeurotrophin signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >> |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN11 (RC220029, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTPN11.
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PTPN11 monoclonal antibody.
Flow cytometric Analysis of Hela cells, using anti-PTPN11 antibody(TA501758),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
Flow cytometric Analysis of Jurkat cells, using anti-PTPN11 antibody(TA501758),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).