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Home Antibody All anti-PTPN11 antibodies

Anti-PTPN11 PHOSPHO Antibody EP508(2)Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301056
  • Rabbit Monoclonal Antibody against PTPN11 (Clone EP508(2)Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for PTPN11 (NM_002834)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 542 of human SHP-2 was used as an immunogen. This antibody detects SHP-2 phosphorylated at Tyrosine 542.
Clone NameEP508(2)Y IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:50,000; ICC: 1: 100; IP: 1:40
Predicted MW Explanation 68 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1
Alternative NameBPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Database LinkNP_002825
Entrez Gene 5781 Human
Entrez Gene 19247 Mouse
FunctionSHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).
Related PathwayPhosphataseDruggable Genome Jak-STAT signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationNeurotrophin signaling pathwayAdipocytokine signaling pathwayEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - SHP2 antibody [EP508(2)Y]; All lanes : Anti-SHP2 (phospho Y542) antibody [EP508(2)Y] at 1/50000 dilution.Lane 1 : NIH/3T3 cell lysates; untreated.Lane 2 : NIH/3T3 cell lysates; treated with PDGF.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP conjugated, at 1/2000 dilution.Predicted band size : 68 kDa.Observed band size : 68 kDa.

 

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