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Anti-PTPN1 TRUEMAB Antibody Clone OTI1A2
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for PTPN1 (NM_002827)
|Full length human recombinant protein of human PTPN1 (NP_002818) produced in HEK293T cell.|
|WB, IF, FC
||WB 1:2000, IF 1:100, FLOW 1:100
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1|
Entrez Gene 5770 Human
|The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]. |
|TransmembranePhosphataseDruggable Genome Adherens junctionInsulin signaling pathway|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN1 (RC204902, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTPN1.
Anti-PTPN1 mouse monoclonal antibody (TA503038) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PTPN1(RC204902).
HEK293T cells transfected with either RC204902 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PTPN1 antibody(TA503038), and then analyzed by flow cytometry.
Flow cytometric Analysis of Hela cells, using anti-PTPN1 antibody(TA503038),(Red), compared to a nonspecific negative control antibody,(Blue).
Flow cytometric Analysis of Jurkat cells, using anti-PTPN1 antibody(TA503038),(Red), compared to a nonspecific negative control antibody,(Blue).