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Home Antibody All anti-PTPN1 antibodies

Anti-PTPN1 PHOSPHO Antibody EP1840Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303675
  • Rabbit monoclonal antibody against PTP1B Phospho (pS378) (EP1840Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for PTPN1 (NM_002827)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding serine 378 of human PTP1B was used as an immunogen. This antibody detects PTP1B phosphorylated on serine 378.
Clone NameEP1840Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500,000 -1,000,000; IHC: 1:50 -100; ICC: 1:100 - 250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1
Alternative NamePTP1B
Database LinkNP_002818
FunctionThe protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq].
Related Pathway
Adherens junction
Hemostasis

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WB Image
Western blot - PTP1B (phospho S378) antibody [EP1840Y]; All lanes : Anti-PTP1B (phospho S378) antibody [EP1840Y] at 1/1000000 dilution.Lane 1 : HeLa cell lysates - untreated.Lane 2 : HeLa cell lysates - treated with calyculin A.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 50 kDa.Observed band size : 50 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PTP1B (phospho S378) antibody [EP1840Y]; TA303675, at a 1/50 dilution, staining human PTP1B (phospho S378) in breast carcinoma by Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

 

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