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Anti-PTN Antibody EPR3041
|A synthetic peptide corresponding to residues near the N-terminus of human Pleiotrophin was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:20000; IP: 1:10
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens pleiotrophin (PTN)|
|HARP; HBGF8; HBNF; NEGF1|
|Pleiotrophin (PTN) is the first member of a recently discovered family of developmentally regulated cytokines. This protein, previously designated heparin-binding growth factor-8, was renamed pleiotrophin to reflect its diverse activities (1). PTN is a member of a highly conserved human gene family of proteins. It has a high affinity for heparin and exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth (2). More recently, PTN was found to be overexpressed in a variety of neuroectodermal tumors and described as an essential angiogenic growth factor in choriocarcinoma and melanoma, promoting metastatic growth. High expression levels of PTN were also found in patients with gastrointestinal malignancies, particularly in those patients with pancreatic cancer (3) |
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Western blot - Pleiotrophin antibody [EPR3041]; All lanes : Anti-Pleiotrophin antibody [EPR3041] at 1/20000 dilution.Lane 1 : NIH/3T3 treated with 2% FBS cell lysate.Lane 2 : Fetal brain tissue lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 19 kDa.Observed band size : 19 kDa.