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Home Antibody All anti-PTK2B antibodies

Anti-PTK2B Antibody YE353

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303508
  • Rabbit monoclonal antibody against Pyk2(YE353)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC406631) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for PTK2B (NM_173174)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human PYK2 was used as immunogen. The antibody does not cross-react with other FAK family members.
Clone NameYE353 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500; IHC: 1:250-500; ICC: 1:100; IP: 1:80
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Reference Data

Target NameHomo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1
Alternative NameCADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Database LinkNP_775266
FunctionThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot - PYK2 antibody [YE353]; Anti-PYK2 antibody [YE353] at 1/5000 dilution + Jurkat cell lysate.Predicted band size : 116 kDa.Observed band size : 116 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - PYK2 antibody [YE353]; Ab32571, at a 1/250 dilution, staining PYK2 in paraffin embedded human normal brain tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - PYK2 antibody [YE353]; Ab32571, at a 1/100 dilution, staining PYK2 in PC12 cells by Immunofluorescence.

 

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