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Home Antibody All anti-PTK2B antibodies

Anti-PTK2B Antibody YE353

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303508
  • Rabbit monoclonal antibody against Pyk2(YE353)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406631) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for PTK2B (NM_173174)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the N-terminus of human PYK2 was used as immunogen. The antibody does not cross-react with other FAK family members.
Clone NameYE353 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500; IHC: 1:250-500; ICC: 1:100; IP: 1:80
Predicted MW Explanation 116 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Reference Data

Target NameHomo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1
Alternative NameCADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Database LinkNP_775266
Entrez Gene 2185 Human
Entrez Gene 19229 Mouse
Entrez Gene 50646 Rat
FunctionThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayProtein KinaseDruggable Genome Calcium signaling pathwayChemokine signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationGnRH signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PYK2 antibody [YE353]; Anti-PYK2 antibody [YE353] at 1/5000 dilution + Jurkat cell lysate.Predicted band size : 116 kDa.Observed band size : 116 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - PYK2 antibody [YE353]; Ab32571, at a 1/250 dilution, staining PYK2 in paraffin embedded human normal brain tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - PYK2 antibody [YE353]; Ab32571, at a 1/100 dilution, staining PYK2 in PC12 cells by Immunofluorescence.

 

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