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Anti-PTK2B Antibody YE353
Also for PTK2B (NM_173174)
|A synthetic peptide corresponding to residues in the N-terminus of human PYK2 was used as immunogen. The antibody does not cross-react with other FAK family members.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:500; IHC: 1:250-500; ICC: 1:100; IP: 1:80
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1|
|CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK|
Entrez Gene 2185 Human
Entrez Gene 19229 Mouse
Entrez Gene 50646 Rat
|This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]. |
|Protein KinaseDruggable Genome Calcium signaling pathwayChemokine signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationGnRH signaling pathway|
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Western blot - PYK2 antibody [YE353]; Anti-PYK2 antibody [YE353] at 1/5000 dilution + Jurkat cell lysate.Predicted band size : 116 kDa.Observed band size : 116 kDa.
Immunohistochemistry (Paraffin-embedded sections) - PYK2 antibody [YE353]; Ab32571, at a 1/250 dilution, staining PYK2 in paraffin embedded human normal brain tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - PYK2 antibody [YE353]; Ab32571, at a 1/100 dilution, staining PYK2 in PC12 cells by Immunofluorescence.