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Home Antibody All anti-PTK2 antibodies

Anti-PTK2 Antibody EP841Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301029
  • Rabbit Monoclonal Antibody against PTK2 (Clone EP841Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403521) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for PTK2 (NM_153831)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding tyrosine 861 of human FAK was used as an immunogen.
Clone NameEP841Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein tyrosine kinase 2 (PTK2), transcript variant 1
Alternative NameFADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71
Database LinkNP_722560
FunctionFocal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- and C-terminal regions. FAK is activated by phosphorylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion or antibody cross-linking or via G-protein-coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid (2-3). Tyrosine 861 on FAK is a major Src phosphorylation site. Phospholyation on tyrosine 861 promotes FAK binding to Intergin (cytoplasmic tail) and leads to FAK mediated anti-apoptotic signaling pathway during hyperosmotic cell stress (4) Increased FAK expression has been correlated with the enhanced motility and invasiveness of human tumor cells, as well as with promoting increased cell proliferation (5).
Related Pathway
Focal Adhesion
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - FAK (phospho Y861) antibody [EP841Y]; All lanes : Anti-FAK (phospho Y861) antibody [EP841Y].Lane 1 : Hela cell lysates, untreated.Lane 2 : Hela cell lysates treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti rabbit at 1/2000 dilution.Predicted band size : 119 kDa.Observed band size : 125 kDa .

 

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