Home Antibody All anti-PTGS1 antibodies
Anti-PTGS1 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for PTGS1 (NM_000962)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
||WB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:250-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1), transcript variant 1|
|COX1; COX3; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS|
Entrez Gene 5742 Human
|Cyclooxygenase (COX), also known as prostaglandin H2 synthese and prostaglandin endoperoxide synthase, is an important enzyme in the conversion of arachidonic acid to prostaglandin H2.1, 2 Prostaglandin H2 is converted by other enzymes into inflammatory mediators such as prostaglandin (PG) D2, PGE2, PGF2a, PG12, and thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. COX consists of two isoforms, COX-I (599 amino acid residues) and COX-II (604 amino acid residues). The COX enzymes, membrane-associated heme proteins that have cyclooxygenase and peroxidase activities, are targets of NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin.3 COX-I is involved in the regulation of homeostatic functions throughout the body, such as vascular hemostasis, renal blood flow, and maintenance of glomerular function.4, 5, 6 It is constitutively produced in most cell types with high expression levels found in gastrointestinal tissues. COX-I is important in the gut for the production of prostaglandins, which inhibit gastric secretion. COX-I can be induced in monocytes, macrophages, and other cells as part of the inflammatory response by IL-1b and other cytokines. It is also induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone.|
|TransmembraneDruggable Genome Arachidonic acid metabolismMetabolic pathways|
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Western Blot: COX1 Antibody - Western Blot was performed using affinity purified SEQer PTGS1 antibody. The lanes contain 5-30ug of a whole cell extract. Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution).