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Home Antibody All anti-PTGDS antibodies

Anti-PTGDS Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301421 Rabbit Polyclonal Antibody against PTGDS 100ul $325 3-7 Days
LC400343 PTGDS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for PTGDS (NM_000954)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenThe epitope recognized by this antibody maps to region within residue 120-190 of human PTGDS. [Swiss-Prot# P41222]
Clone Name IsotypeIgG
Species Reactivityhuman, feline, bovine, rabbit, dog, rat, mouse, primate Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB:2 ug/ml
BufferPBS + 30% glycerol and 0.1% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens prostaglandin D2 synthase 21kDa (brain) (PTGDS)
Alternative NameL-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Database LinkNP_000945
Entrez Gene 5730 Human
Entrez Gene 19215 Mouse
Entrez Gene 25526 Rat
Entrez Gene 403740 Dog
FunctionThe protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer? disease.
Related Pathway Arachidonic acid metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Detection of PTGDS in human brain lysates at 0.5 and 2.0 ug/ml.
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