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Home Antibody All anti-PTGDS antibodies

Anti-PTGDS Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301420
  • Rabbit Polyclonal Antibody against PTGDS
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400343) , 20ug
100ul 325 In Stock
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WB(1)
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Also for PTGDS (NM_000954)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThe epitope recognized by this antibody maps to region within residue 1-50 of human PTGDS. [Swiss-Prot# P41222]
Clone Name IsotypeIgG
Species Reactivityhuman, primate, mouse, rat, bovine, porcine, feline, equine, dog Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB:2 ug/ml
BufferPBS + 30% glycerol and 0.1% sodium azide
Purification Immunogen affinity purified

Reference Data

Target NameHomo sapiens prostaglandin D2 synthase 21kDa (brain) (PTGDS)
Alternative NameL-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
Database LinkNP_000945
FunctionThe protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer? disease.
Related Pathway

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WB Image
Detection of PTGDS in human brain lysates at 0.5 and 2.0 ug/ml

 

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