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Home Antibody All anti-PTBP1 antibodies

Anti-PTBP1 Antibody EPR9048(B)


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310792 Rabbit Monoclonal antibody against PTBP1 100ul $325 In Stock
LC419090 PTBP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PTBP1 was used as an immunogen.
Clone NameEPR9048(B) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250; ICC/IF: 1:250 - 1:500
Predicted MW Explanation 57 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1
Database LinkNP_002810
Entrez Gene 5725 Human
Entrez Gene 19205 Mouse
Entrez Gene 29497 Rat
FunctionPTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. PTBP1 has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. It binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. PTBP1 is localized in the nucleoplasm and it is also detected in the perinucleolar structure (1).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-PTBP1 antibody [EPR9048(B)]; All lanes : Anti-PTBP1 antibody [EPR9048(B)] at 1/10000 dilution.Lane 1 : Human fetal liver lysate.Lane 2 : Jurkat cell lysate.Lane 3 : Daudi cell lysate.Lane 4 : A549 cell lysate.Lane 5 : BxPC3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 57 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTBP1 antibody [EPR9048(B)]; Immunohistochemical analysis of PTBP1 in paraffin embedded Human breast carcinoma tissue stained with TA310792 at a 1/100 dilution.
Immunocytochemistry/ Immunofluorescence - Anti-PTBP1 antibody [EPR9048(B)]; Immunofluorescent staining of PTBP1 in A549 cells, using TA310792 at a 1/250 dilution.


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