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Also for PSMC3 (NM_002804)
|Recombinant fragment corresponding to a region within amino acids 51 and 361 of PSMC3 (Uniprot ID#P17980)|
|Human (Predicted: Mouse, Zebrafish, Xenopus Tropicalis, Chicken, Rhesus Monkey, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:5000-1:20000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Zebrafish (100%), Xenopus Tropicalis (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
|Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 3 (PSMC3)|
Entrez Gene 5702 Human
Entrez Gene 19182 Mouse
Entrez Gene 713356 Monkey
|The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq]|
|Transcription FactorsDruggable Genome Proteasome|
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Sample (30 ug of whole cell lysate). A: MOLT4 . 10% SDS PAGE. TA308441 diluted at 1:5000
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft , using PSMC3(TA308441) antibody at 1:500 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed A549, using PSMC3(TA308441) antibody at 1:200 dilution.