Home All anti-PSMA7 antibodies
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Also for PSMA7 (NM_002792)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 175 of proteasome alpha 7|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7)|
|C6; HSPC; RC6-1; XAPC7|
|The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. [provided by RefSeq]|
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A: A431 B: H1299 (anti-PSMA7 antibody diluted at 1:1000)
A: mouse brain (anti-PSMA7 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded DLD-1 xenograft, using proteasome alpha 7(anti-PSMA7 antibody) antibody at 1:100 dilution.