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Home Antibody All anti-PSENEN antibodies

Anti-PSENEN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306367
  • Rabbit Polyclonal PEN2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403539) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for PSENEN (NM_172341)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPEN2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, IF
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens presenilin enhancer gamma secretase subunit (PSENEN), transcript variant 1
Alternative NameMDS033; MSTP064; PEN-2; PEN2
Database LinkNP_758844
FunctionPEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A?beta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer’s disease.
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
Western blot analysis of PEN2 in K562 cell lysate with PEN2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunofluorescence of PEN2 in K562 cells with PEN2 antibody at 20 ug/mL.

 

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