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Home Antibody All anti-PSEN1 antibodies

Anti-PSEN1 PHOSPHO Antibody EP2001Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301220
  • Rabbit Monoclonal Antibody against PSEN1 (Clone EP2001Y) (Phospho-specific)
100ul $325 3-7 Days
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WB(1)
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Also for PSEN1 (NM_000021)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 310 of human Presenilin 1 was used as an immunogen. This antibody detects Presenilin 1 phosphorylated on serine 310
Clone NameEP2001Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:5000~10,000; ICC: 1: 100~250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens presenilin 1 (PSEN1), transcript variant 1
Alternative NameAD3; FAD; PS-1; PS1; S182
Database LinkNP_000012
FunctionPresenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). Phosphorylation at serine 310 by PKACa has been linked to its proteolytic processing and apoptosis regulation (3). Heterogenous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of 35 kDa and 20 kDa respectively. During apoptosis, CTF is further cleaved by caspase-3 to produce PSI-CTF12 fragment.
Related Pathway
Delta-Notch Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot - Presenilin 1 (phospho S310) antibody [EP2001Y]; All lanes : Anti-Presenilin 1 (phospho S310) antibody [EP2001Y] at 1/5000 dilution.Lane 1 : Jurkat cell lysates untreated.Lane 2 : Jurkat cell lysates treated with 200 nM TPA, 30 minutes at 37C, serum-free.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 23 kDa .

 

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