Home Antibody All anti-PRSS12 antibodies
Also for PRSS12 (NM_003619)
|Neurotrypsin antibody was raised against a 23 amino acid peptide from near the amino terminus of human neurotrypsin.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens protease, serine, 12 (neurotrypsin, motopsin) (PRSS12)|
|BSSP-3; BSSP3; MRT1|
Entrez Gene 8492 Human
Entrez Gene 19142 Mouse
Entrez Gene 85266 Rat
|Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.|
|Secreted ProteinProteaseDruggable Genome |
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Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 ug/ml.