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Home Antibody All anti-PRPF19 antibodies

Anti-PRPF19 Antibody EPR7446

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310784
  • Rabbit Monoclonal antibody against PRP19
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402343) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(2)
Assay(1)
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Also for PRPF19 (NM_014502)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PRP19 was used as an immunogen.
Clone NameEPR7446 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC: 1:250 - 1:500; FC: 1:100 - 1:500
Predicted MW Explanation 55 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens pre-mRNA processing factor 19 (PRPF19)
Alternative NamehPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4
Database LinkNP_055317
Entrez Gene 27339 Human
Entrez Gene 28000 Mouse
Entrez Gene 246216 Rat
FunctionPRP19, an essential RNA splicing factor, is a core component of the spliceosomal NinTeen associated-Complex (NTC), a sub-complex required for the activation of the spliceosome. It plays a direct role in the activation and structural stabilization of the spliceosome. PRP19 utilizes its N-terminal U-box domain to recruit Ubc3, and possibly other E2 conjugating enzymes (1). In addition, it is involved in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. PRP19 binds double-stranded DNA in a sequence-nonspecific manner (2).
Related PathwayDruggable Genome SpliceosomeUbiquitin mediated proteolysis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-PRP19 antibody [EPR7446]; All lanes : Anti-PRP19 antibody [EPR7446] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A431 cell lysate.Lane 3 : MCF7 cell lysate.Lane 4 : PC12 cell lysate.Lane 5 : NIH 3T3 cell lysate.Lane 6 : HeLa cell lysate.Lane 7 : K562 cell lysate.Lane 8 : U937 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 55 kDa.
Assay Image
Other-Anti-PRP19 antibody [EPR7446](TA310784); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRP19 antibody [EPR7446]; TA310784, at 1/50 dilution, staining PRP19 in Paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRP19 antibody [EPR7446]; TA310784, at 1/50 dilution, staining PRP19 in Paraffin-embedded Human colon carcinoma tissue by Immunohistochemistry.

 

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