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Anti-PRKDC PHOSPHO Antibody EPR2251
Also for PRKDC (NM_006904)
|A phospho specific peptide corresponding to residues surrounding serine 2612 of human DNA-PK/PRKDC was used as an immunogen. This antibody only detects DNA-PK/PRKDC phosphorylated at serine 2612.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1|
|DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7|
Entrez Gene 5591 Human
|DNA-PK/PRKDC, the catalytic subunit of the DNA-dependent protein kinase, is a member of the PI3/PI4-kinase family. It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination (1). Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex. DNA-PK phosphorylates Hsp90, p53 and c-Jun (2,3). |
|Protein KinaseDruggable Genome Non-homologous end-joiningCell cycle|
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Western blot - Anti-DNA PKcs (phospho S2612) antibody [EPR2251]; All lanes : Anti-DNA PKcs (phospho S2612) antibody [EPR2251] at 1/1000 dilution.Lane 1 : Lysate of LNCaP cells, untreated .Lane 2 : Lysate of LNCaP cells treated with alkaline phosphatase.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 469 kDa.