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Home Antibody All anti-PRKDC antibodies

Anti-PRKDC Antibody Y393

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303663
  • Rabbit monoclonal antibody against PRKDC / DNA-PK (Y393)
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human DNA-PK was used as immunogen. This antibody may detect splice isoform 2 according to sequence analysis.
Clone NameY393 IsotypeIgG
Species ReactivityMouse, Rat, Human, Armenian Hamster ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1,000; IHC: 1:50; ICC: 1:250-500
Predicted MW Explanation 469 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Reference Data

Target NameHomo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1
Alternative NameDNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7
Database LinkNP_008835
Entrez Gene 5591 Human
Entrez Gene 19090 Mouse
Entrez Gene 360748 Rat
FunctionThe PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM].
Related PathwayProtein KinaseDruggable Genome Non-homologous end-joiningCell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - DNA PKcs antibody [Y393]; Anti-DNA PKcs antibody [Y393] at 1/1000 dilution + K562 cell lysate.Predicted band size : 469 kDa.Observed band size : 460 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DNA PKcs antibody [Y393]; Ab32566, at a 1/50 dilution, staining DNA PKcs in paraffin embedded human breast carcinoma tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - DNA PKcs antibody [Y393]; Ab32566, at a 1/250 dilution, staining DNA PKcs in Hela cells by Immunocytochemistry/Immunofluorescence.

 

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