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Anti-PRKDC Antibody Y393
Also for PRKDC (NM_006904)
|A synthetic peptide corresponding to residues in the C-term of human DNA-PK was used as immunogen. This antibody may detect splice isoform 2 according to sequence analysis.|
|Mouse, Rat, Human, Armenian Hamster
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1:1,000; IHC: 1:50; ICC: 1:250-500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1|
|DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; IMD26; p350; XRCC7|
Entrez Gene 5591 Human
Entrez Gene 19090 Mouse
Entrez Gene 360748 Rat
|The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM]. |
|Protein KinaseDruggable Genome Non-homologous end-joiningCell cycle|
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Western blot - DNA PKcs antibody [Y393]; Anti-DNA PKcs antibody [Y393] at 1/1000 dilution + K562 cell lysate.Predicted band size : 469 kDa.Observed band size : 460 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DNA PKcs antibody [Y393]; Ab32566, at a 1/50 dilution, staining DNA PKcs in paraffin embedded human breast carcinoma tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - DNA PKcs antibody [Y393]; Ab32566, at a 1/250 dilution, staining DNA PKcs in Hela cells by Immunocytochemistry/Immunofluorescence.