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Anti-PRKCD PHOSPHO Antibody EPR1485Y
Also for PRKCD (NM_006254)
|A phospho-specific peptide corresponding to residues surrounding Threonine 507 of human PKC delta was used as an immunogen. This antibody detects PKC delta phosphorylated at T507.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens protein kinase C, delta (PRKCD), transcript variant 1|
|CVID9; MAY1; nPKC-delta; PKCD|
Entrez Gene 5580 Human
|PKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3). |
|Protein KinaseDruggable Genome Chemokine signaling pathwayVascular smooth muscle contractionTight junctionFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >> |
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Western blot - PKC delta (phospho T507) antibody [EPR1485Y]; All lanes : Anti-PKC delta (phospho T507) antibody [EPR1485Y] at 1/500 dilution.Lane 1 : U937 cell lysate.Lane 2 : U937 cell lysate treated with TPA.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 77 kDa.Observed band size : 77 kDa.