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Anti-PRKCD PHOSPHO Antibody EPR1485Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against PRKCD (Clone EPR1485Y) (Phospho-specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Threonine 507 of human PKC delta was used as an immunogen. This antibody detects PKC delta phosphorylated at T507.
Clone NameEPR1485Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein kinase C, delta (PRKCD), transcript variant 1
Alternative NameALPS3; CVID9; MAY1; nPKC-delta; PKCD
Database LinkNP_006245
Entrez Gene 5580 Human
FunctionPKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3).
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathwayVascular smooth muscle contractionTight junctionFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
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Western blot - PKC delta (phospho T507) antibody [EPR1485Y]; All lanes : Anti-PKC delta (phospho T507) antibody [EPR1485Y] at 1/500 dilution.Lane 1 : U937 cell lysate.Lane 2 : U937 cell lysate treated with TPA.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 77 kDa.Observed band size : 77 kDa.


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