Home Antibody All anti-PRKCB1 antibodies
Also for PRKCB1 (NM_002738)
|This PKC beta2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 642-673 amino acids from the C-terminal region of human PKC beta2.|
|Human, Mouse, Rat, Monkey
||WB: 1:1000, IHC: 1:10~50
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
|Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2|
|PKC-beta; PKCB; PRKCB1; PRKCB2|
Entrez Gene 5579 Human
Entrez Gene 18751 Mouse
Entrez Gene 25023 Rat
Entrez Gene 701195 Monkey
|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.|
|Protein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayCalcium signaling pathwayChemokine signaling pathwayPhosphatidylinositol signaling systemVascular smooth muscle contractionMore Pathways >> |
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
The anti-PKC beta2 Pab (Cat. #TA302123) is used in Western blot to detect PKC beta2 in Jurkat cell lysate (lane 1) and mouse brain tissue lysate (lane 2).
Formalin-fixed and paraffin-embedded human brain tissue reacted with PKC beta2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.