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Home Antibody All anti-PRKCA antibodies

Anti-PRKCA Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308938
  • Rabbit Polyclonal antibody to PKC alpha (protein kinase C, alpha)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400966) , 20ug Explanation
100ul 325 3-7 Days
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WB(2)
IHC(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 250 of PKC alpha (Uniprot ID#P17252)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Rhesus Monkey) Concentration0.69mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 77kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens protein kinase C, alpha (PRKCA)
Alternative NameAAG6; PKC-alpha; PKCA; PRKACA
Database LinkNP_002728
Entrez Gene 5578 Human
Entrez Gene 18750 Mouse
Entrez Gene 718412 Monkey
FunctionProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq]
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVascular smooth muscle contractionWnt signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308938 diluted at 1:1000.
WB Image
Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. TA308938 diluted at 1:1000.
IHC Image
Immunohistochemical analysis of paraffin-embedded Colon ca, using PKC alpha(TA308938) antibody at 1:500 dilution.

 

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