OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-PRKAR2B antibodies

Anti-PRKAR2B Antibody EP2648

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301360
  • Rabbit Monoclonal Antibody against PRKAR2B (Clone EP2648)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419138) , 20ug
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
IHC(1)
spacer
Also for PRKAR2B (NM_002736)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human PKA, RIIb was used as an immunogen.
Clone NameEP2648 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:5000 - 1:20000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B)
Alternative NamePRKAR2; RII-BETA
Database LinkNP_002727
FunctioncAMP-dependent protein kinase (PKA) mediates cyclic AMP, an important second messenger in the coordinated regulation of cellular metabolism. PKA is assembled from two regulatory and two catalytic subunits. The RII beta (RIIb) regulatory isoform is abundant in brown and white adipose tissue and brain, with limited expression elsewhere. RIIb is demonstrated to play a role in regulating energy balance and adiposity, thus making it a potential target for therapeutic intervention in obesity (1, 2). It has been shown that RIIb is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. This suggests that the RIIb cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation (3).
Related Pathway
Cell cycle

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKA 2 beta (regulatory subunit) antibody [EP2648]; All lanes : Anti-PKA 2 beta (regulatory subunit) antibody [EP2648] at 1/20000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Human testis lysate.Lane 3 : NIH/3T3 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 46 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PKA 2 beta (regulatory subunit) antibody [EP2648]; TA301360, at 1/100 dilution, staining PKA 2 beta (regulatory subunit) in paraffin-embedded human brain tissue by Immunohistochemistry.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title