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Home All anti-PRKAA2 antibodies

Anti-PRKAA2 Phospho Antibody EPR3052

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA307811
  • Rabbit monoclonal antibody against AMPK alpha 2 Phospho (pS491)(clone EPR3052) (Phospho-Specific)
100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
30ul
$100
$50*
In Stock
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* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
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Also for PRKAA2 (NM_006252)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 491 of human AMPK alpha 2 was used as an immunogen. This antibody only detects AMPK alpha 2 phosphorylated at Serine 491.
Clone NameEPR3052 IsotypeRabbit IgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000,
BufferStore at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens protein kinase, AMP-activated, alpha 2 catalytic subunit (PRKAA2)
Alternative NameAMPK; AMPK2; AMPKa2; PRKAA
Database LinkNP_006243
FunctionAMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Related Pathway

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WB Image
Western blot analysis on 293T cell lysates using anti-Phospho-AMPK alpha 2 (pS491) RabMAb .

 

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