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Home Antibody All anti-PRDM16 antibodies

Anti-PRDM16 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306900
  • Rabbit Polyclonal PRDM16 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC411786) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for PRDM16 (NM_022114)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PRDM16.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens PR domain containing 16 (PRDM16), transcript variant 1
Alternative NameCMD1LL; LVNC8; MEL1; PFM13
Database LinkNP_071397
FunctionPRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Related Pathway

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WB Image
Western blot analysis of PRDM16 in rat brain tissue lysate with PRDM16 antibody at (A) 1 and (B) 2 ug/mL.
IHC Image
Immunohistochemistry of PRDM16 in rat brain tissue with PRDM16 antibody at 2.5 ug/mL.

 

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